Drug resistance in epithelial ovarian cancer: P-glycoprotein and glutation S-transferase. Can they play an important role in detecting response to platinum-based chemotherapy as a first-line therapy

Simsek, TAYUP; Ozbilim, GÜLAY; Gulkesen, KEMAL; KAYA, H; Sargin, FATİH; Karaveli, S

Drug resistance in epithelial ovarian cancer: P-glycoprotein and glutation S-transferase. Can they play an important role in detecting response to platinum-based chemotherapy as a first-line therapy

Simsek T., Ozbilim G., Gulkesen H., KAYA H., Sargin F., Karaveli S.

EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, cilt.22, sa.6, ss.436-438, 2001 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 22 Sayı: 6
Basım Tarihi: 2001
Dergi Adı: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.436-438
Anahtar Kelimeler: glutation S-transferase, P-glycoprotein, ovarian cancer, drug resistance, EXPRESSION, MODULATION, MECHANISMS, BENIGN, TUMORS
Akdeniz Üniversitesi Adresli: Evet

Özet

Objective: Drug resistance is important For the treatment of ovarian cancer. P-glycoprotein and glutation S-tranferase as resistance markers play an important role in the effectivity of chemotherapeutical agents. The role of P-glycoprotein and glutation S-transferase in the treatment of epithelial ovarian cancer is not well understood. We investigated the relation between P-glycoprotein and glutation S-transferase level for response to platinum-based chemotherapy in epithelial ovarian cancer.