Novel polymorphisms in ovine prion protein gene

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Meydan H., ÖZKAN M., YILDIZ M. A., Goldmann W.

ANIMAL GENETICS, vol.44, no.5, pp.588-591, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.1111/age.12019
  • Journal Name: ANIMAL GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.588-591
  • Keywords: gene variability, PRNP gene, Turkish native sheep, PRP GENE, SHEEP, SCRAPIE, RESISTANCE, AGENT, GOATS, BREED
  • Akdeniz University Affiliated: No

Abstract

The aim of this study was to identify the PRNP polymorphisms outside the standard codons
136, 154 and 171 in 1110 sheep with no clinical sign of scrapie from all 18 Turkish native
sheep breeds and compare our results with published data on ovine PRNP polymorphism
from other regions of the world. Among the 22 amino acid polymorphisms and three silent
mutations, 10 were novel for ovine PRNP: p.Gly94Gly, p.Leu128Ile, p.Met132Leu,
p.Ser135Arg, p.Met137Val, p.Asn146Lys, p.Arg159Arg, p.Tyr160Asn, p.Gln163His and
p.Thr193Ser. These data reveal that sheep breeds close to the historic center of small
ruminant domestication have remained highly diverse in the prion gene locus, with
distinctive genetic similarities to both Asian and European sheep breeds.

The aim of this study was to identify the PRNP polymorphisms outside the standard codons 136, 154 and 171 in 1110 sheep with no clinical sign of scrapie from all 18 Turkish native sheep breeds and compare our results with published data on ovine PRNP polymorphism from other regions of the world. Among the 22 amino acid polymorphisms and three silent mutations, 10 were novel for ovine PRNP: p.Gly94Gly, p.Leu128Ile, p.Met132Leu, p.Ser135Arg, p.Met137Val, p.Asn146Lys, p.Arg159Arg, p.Tyr160Asn, p.Gln163His and p.Thr193Ser. These data reveal that sheep breeds close to the historic center of small ruminant domestication have remained highly diverse in the prion gene locus, with distinctive genetic similarities to both Asian and European sheep breeds.