Akademik Veri Yönetim Sistemi
European journal of geriatrics and gerontology (Online), cilt.6, sa.2, ss.160-162, 2024 (Hakemli Dergi)
The pathophysiology of sarcoidosis includes defective T cells and macrophages, which lead to the formation of granulomas. On the other hand, increased turnover of osteoclasts has been observed in Paget’s disease, where osteoclasts are a member of the macrophage family. There may be a common intrinsic factor associated with the vitamin D receptor gene receptor that triggers the defective activation of macrophages in both disorders. More than half of patients with Paget’s disease are asymptomatic; thus, the coexistence of the two disorders may go unnoticed. To the best of our knowledge, the coexistence of Paget’s disease and pulmonary sarcoidosis in the same patient has not been previously reported. Whether bisphosphonate can be used for the treatment of osseos sarcoidosis is a subject for future research. Herein, we report a case of Paget’s disease in an older patient with pulmonary sarcoidosis.