Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin

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Ercan S., Kencebay C., Basaranlar G., Ozcan F., DERİN N., Aslan M.

LIPIDS IN HEALTH AND DISEASE, vol.14, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2015
  • Doi Number: 10.1186/s12944-015-0008-3
  • Journal Name: LIPIDS IN HEALTH AND DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Sodium metabisulfite, Ghrelin, Polyunsaturated fatty acids, POLYUNSATURATED FATTY-ACIDS, ANTIOXIDANT ENZYME-ACTIVITY, VISUAL-EVOKED POTENTIALS, INDUCED OXIDATIVE STRESS, ALVEOLAR MACROPHAGES, LIPID MEDIATORS, SULFUR-DIOXIDE, S-SULFONATES, SULFITE, PLASMA
  • Akdeniz University Affiliated: Yes

Abstract

Background: Sodium metabisulfite is commonly used as preservative in foods but can oxidize to sulfite radicals initiating molecular oxidation. Ghrelin is a peptide hormone primarily produced in the stomach and has anti-inflammatory effects in many organs. This study aimed to assess endogenous omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) in rat peripheral organs following sodium metabisulfite treatment and determine the possible effect of ghrelin on changes in n-6 inflammatory pathway.