Association of circulating sTRAIL and high-sensitivity CRP with type 2 diabetic nephropathy and foot ulcers

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Arik H. O., Yalcin A. D., GÜMÜŞLÜ S., Genc G. E., Turan A., ŞANLIOĞLU A. D.

MEDICAL SCIENCE MONITOR, vol.19, pp.712-715, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19
  • Publication Date: 2013
  • Doi Number: 10.12659/msm.889514
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.712-715
  • Keywords: soluble TRAIL, type-2 diabetes mellitus, diabetic nephropathy, diabetic foot, hsCRP, HbA1c, Wagner grading system, APOPTOSIS-INDUCING-LIGAND, METASTATIC COLON-CANCER, SOLUBLE TRAIL LEVELS, RECEPTOR, DEATH, DISEASE, ATHEROSCLEROSIS, OSTEOPROTEGERIN, RISK
  • Akdeniz University Affiliated: Yes

Abstract

Background: Hyperglycemia is among the potent factors that may induce or facilitate apoptosis. TNF-Related Apoptosis-Inducing Factor (TRAIL) is known for its apoptotic and immunomodulatory effects that have recently been correlated with diabetes. We examined serum-soluble TRAIL (sTRAIL) and high-sensitivity CRP (hs-CRP) levels and their association with various distinct parameters in type 2 diabetic nephropathy patients with diabetic foot disease.