Clinical outcome in IL-10-and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation


Engelhardt K. R., Shah N., Faizura-Yeop I., KOCACIK UYGUN D. F., Frede N., Muise A. M., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.131, no.3, pp.825-839, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 131 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jaci.2012.09.025
  • Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.825-839
  • Keywords: IL-10, IL-10 receptor, enterocolitis, mutations, colectomy, hematopoietic stem cell transplantation, INFLAMMATORY-BOWEL-DISEASE, INTERLEUKIN-10 RECEPTOR, CROHNS-DISEASE, MUTATIONS, CYTOKINE, COMPLEX, IMMUNODEFICIENCY, FAMILY, GENE
  • Akdeniz University Affiliated: Yes

Abstract

Background: Inherited deficiencies of IL-10 or IL-10 receptor (IL-10R) lead to immune dysregulation with life-threatening early-onset enterocolitis.