Clinical outcome in IL-10-and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation

Engelhardt K. R., Shah N., Faizura-Yeop I., KOCACIK UYGUN D. F., Frede N., Muise A. M., ...Daha Fazla

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.131, sa.3, ss.825-839, 2013 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 131 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jaci.2012.09.025
  • Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.825-839
  • Anahtar Kelimeler: IL-10, IL-10 receptor, enterocolitis, mutations, colectomy, hematopoietic stem cell transplantation, INFLAMMATORY-BOWEL-DISEASE, INTERLEUKIN-10 RECEPTOR, CROHNS-DISEASE, MUTATIONS, CYTOKINE, COMPLEX, IMMUNODEFICIENCY, FAMILY, GENE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Inherited deficiencies of IL-10 or IL-10 receptor (IL-10R) lead to immune dysregulation with life-threatening early-onset enterocolitis.