Tumor necrosis factor-related apoptosis inducing ligand-R4 decoy receptor expression is correlated with high Gleason scores, prostate-specific antigen recurrence, and decreased survival in patients with prostate carcinoma

KÖKSAL İ. T., ŞANLIOĞLU A. D., Karacay B., Griffith T. S., ŞANLIOĞLU S.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, cilt.26, sa.2, ss.158-165, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.urolonc.2007.01.022
  • Dergi Adı: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.158-165
  • Anahtar Kelimeler: tumor necrosis factor-related apoptosis inducing ligand, Gleason scoring, prostate-specific antigen recurrence, prostate cancer, RADICAL PROSTATECTOMY, CANCER CELLS, E-CADHERIN, TRAIL, PROGRESSION, ADENOVIRUS, THERAPY, SERUM, GENE, COMBINATION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective: Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has recently been investigated because of its ability to selectively kill cancer cells. Despite recent publications mainly focusing on TRAIL resistance in cancer cells, little is known about how TRAIL contributes to the carcinogenesis process. Because the expression patterns of TRAIL and its receptors in patients with prostate carcinoma have recently been reported, this study investigated the significance of TRAIL and TRAIL receptor expression in connection to serum prostate-specific antigen (PSA) and Gleason scoring.