Tumor necrosis factor-related apoptosis inducing ligand-R4 decoy receptor expression is correlated with high Gleason scores, prostate-specific antigen recurrence, and decreased survival in patients with prostate carcinoma

KÖKSAL İ. T., ŞANLIOĞLU A. D., Karacay B., Griffith T. S., ŞANLIOĞLU S.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, vol.26, no.2, pp.158-165, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1016/j.urolonc.2007.01.022
  • Journal Name: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.158-165
  • Keywords: tumor necrosis factor-related apoptosis inducing ligand, Gleason scoring, prostate-specific antigen recurrence, prostate cancer, RADICAL PROSTATECTOMY, CANCER CELLS, E-CADHERIN, TRAIL, PROGRESSION, ADENOVIRUS, THERAPY, SERUM, GENE, COMBINATION
  • Akdeniz University Affiliated: Yes

Abstract

Objective: Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has recently been investigated because of its ability to selectively kill cancer cells. Despite recent publications mainly focusing on TRAIL resistance in cancer cells, little is known about how TRAIL contributes to the carcinogenesis process. Because the expression patterns of TRAIL and its receptors in patients with prostate carcinoma have recently been reported, this study investigated the significance of TRAIL and TRAIL receptor expression in connection to serum prostate-specific antigen (PSA) and Gleason scoring.