All-trans retinoic acid prevents cisplatin-induced nephrotoxicity in rats


Yücel C., YUCEL E. E., ARSLAN F. D., EKMEKCI S., KISA E., ULKER V., ...More

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, vol.392, no.2, pp.159-164, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 392 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.1007/s00210-018-01603-0
  • Journal Name: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.159-164
  • Keywords: Nephrotoxicity, All-trans retinoic acid, Cisplatin, INJURY
  • Akdeniz University Affiliated: Yes

Abstract

The aim of this study is to investigate the effects of all-trans retinoic acid (ATRA) use on cisplatin (CP)-induced nephrotoxicty. Twenty-eight rats were randomly divided into four groups. The rats in the control group were injected a single dose of 1ml/kg saline intra-peritoneally (IP) during 10days. The rats in the ATRA group were injected a single dose of ATRA during 10days. The rats in the ATRA+CP group were injected a single dose of CP on the fourth day of the 10days of ATRA treatment. The rats in the CP group were injected a single dose of CP on the fourth day of 10days without administering a treatment. After treatment, the groups were compared with regard to total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels in renal tissue and renal histopathology. The serum creatinine and urea values were statistically significantly higher in the CP group compared to the other groups. The serum creatinine and urea values were statistically significantly lower in the ATRA+CP group when compared to the CP group. Although the TOS and OSI levels were found to be lower in the ATRA+CP group compared to the CP group, the difference was not statistically significant. Administration of ATRA together with CP was observed to reduce the histopathologic destruction in the kidney and lead to mild tubular degeneration, vacuolization, and necrosis (57.1% grade 1; 28.6% grade2, and 14.3% grade 3 necrosis). The results of the present study have revealed that ATRA administration ameliorates CP-induced nephrotoxicity; however, further studies are required to identify this issue before clinical application.