Growth failure, tardive dyskinesia, megacolon development, and hepatic damage in neonatal rats following exposure to trimethobenzamide in utero

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Erol A. Y., Gokcimen A., ÖZDEMİR O.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.24, no.9, pp.1176-1180, 2011 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 24 Issue: 9
• Publication Date: 2011
• Doi Number: 10.3109/14767058.2010.536867
• Journal Name: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1176-1180
• Keywords: Trimethobenzamide, growth failure, tardive dyskinesia, megacolon, histopathology, liver, pregnancy, rat, TASTE-AVERSION, NAUSEA, REGENERATION
• Akdeniz University Affiliated: No

Abstract

Objective. Trimethobenzamide (TMB) has a pregnancy category C labeling. Tardive dyskinesia and gastrointestinal involvement in neonates were not described earlier. We aimed to investigate neurological, developmental, and hepatic effects of TMB.