Tissue and blood levels of zinc, copper, and magnesium in nitric oxide synthase blockade-induced hypertension

Senturk U., Kaputlu I., Gunduz F., Kuru O., Gokalp O.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.77, sa.2, ss.97-106, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 2
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1385/bter:77:2:97
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.97-106
  • Anahtar Kelimeler: nitric oxide, nitric oxide synthase, hypertension, zinc, copper, magnesium, RATS, PRESSURE, ENDOTHELIUM, DEFICIENCY, SERUM, SUPPLEMENTATION, ERYTHROCYTES, RELAXATION, MG2+
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The aim of this study was to determine the levels of tissue and blood zinc (Zn), copper (Cu), magnesium (Mg) in nitric oxide (NO) synthase blockade-induced hypertension. A group of albino rats received a NO synthase inhibitor, N-G-nitro-L-arginine-methyl ester (L-NAME, 60 mg/kg/d) in their drinking water for 21 d. L-NAME intake caused a progressive rise in this group's resting mean arterial blood pressure compared to a control group (p < 0.01). There were no differences between the groups with regard to tissue and blood levels of Zn or Cu; however, Mg concentrations were significantly lower in the hypertensive rats' erythrocytes (20.2% reduction from control levels), cerebral cortex (17.0%), heart (9.1%), renal cortex (12%), renal medulla (16.7%), and in the tissues of the caval vein (23.7%), mesenteric artery (29.8%), renal artery (18.4%), and renal vein (22.1%). There were no significant Mg concentration changes in the hypertensive group's plasma, cerebellum, liver, duodenum, or aortal tissue. These findings suggest that Mg depletion may play a role in the blood pressure rise that occurs in the model of chronic NO synthase inhibition-induced hypertension.