Yttrium-90 Radioembolization in Patients with Unresectable Liver Metastases: Determitning the Factors that Lead to Treatment Efficacy

Gunduz S., Özgür Ö., Bozcuk H., Coşkun H. Ş., Ozdogan M., Erkılıç M., ...Daha Fazla

HEPATO-GASTROENTEROLOGY, cilt.61, sa.134, ss.1529-1534, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 134
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5754/hge13654
  • Dergi Adı: HEPATO-GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1529-1534
  • Anahtar Kelimeler: Liver metastases, selective internal radiation therapy (SIRT), yttrium-90, international normalized ratio (INR), INTERNAL RADIATION-THERAPY, HEPATIC METASTASES, BREAST-CANCER, MICROSPHERES, CHEMOTHERAPY, RADIOEMBOLISATION, FLUOROURACIL, MALIGNANCIES, SURVIVAL, TRIAL
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction: Locoregional treatments, such as radioembolization, can be used to treat patients with unresectable liver metastases. We aimed to determine the progression-free survival and factors that predict survival of patients with liver metastases whose response to selective internal radiation therapy (SIRT) with Y-90 was assessed by positron emission tomography-computled tomography (PET-CT). Patients: Our study included 78 liver cancer patients who were treated with Y-90 radioembolization.Results: The post-treatment response Fates were as follows: 7 patients (9%) had stable disease (SD), 26 patients (33.3%) had a partial response (PR), 4 patients (5.1%) had a complete response (CR). The median hepatic progression-free survival (HPFS) was 4.4 months while median overall survival was 10.1 months. Univariate analysis revealed that HPFS is significantly affected by international normalized ratio (INR) levels and age (Hazard Ratio(HR)=0.54 (95%CI:0.30-096), P=0.034, HR=1.03(95%CI:1.00-1.05), P=0.051). Howlever, only INR levels retained significance with multivariate analysis (HR=0.53 (95%CI:0.30-0.93), P=0.028) while age had limited significance (HR =1.02 (95% CI:1.00-1.05), P=0.051). Conclusion: We determinedi that Y-90 radioembolization is effective as a salvage therapy in patients with predominant liver metastases For the first time, we showed that age and INR values reflecting the functional hepatic reserve can be used as positive predictive factors for HPFS.