Neurological soft signs might be endophenotype candidates for patients with deficit syndrome schizophrenia

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ALBAYRAK Y., Akyol E. S., BEYAZYÜZ M., Baykal S., Kuloglu M.

NEUROPSYCHIATRIC DISEASE AND TREATMENT, vol.11, pp.2825-2831, 2015 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 11
  • Publication Date: 2015
  • Doi Number: 10.2147/ndt.s91170
  • Journal Name: NEUROPSYCHIATRIC DISEASE AND TREATMENT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2825-2831
  • Keywords: biomarker, psychosis, sign, clinical subtypes of schizophrenia, RELIABILITY, DISORDERS, SCHEDULE, VALIDITY
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

Background: Schizophrenia is a chronic, disabling, disorder that affects approximately 1% of the population. The nature of schizophrenia is heterogeneous, and unsuccessful efforts to subtype this disorder have been made. Deficit syndrome schizophrenia (DS) is a clinical diagnosis that has not been placed in main diagnostic manuals. In this study, we aimed to investigate and compare neurological soft signs (NSS) in DS patients, non-deficit schizophrenia (NDS) patients, and healthy controls (HCs). We suggest that NSS might be an endophenotype candidate for DS patients.