Synergic and comparative effect of 5-fluorouracil and leucoverin on breast and colon cancer cells through TRPM2 channels

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Guler Y., Ovey I. S.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.119, no.11, pp.692-700, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 119 Issue: 11
  • Publication Date: 2018
  • Doi Number: 10.4149/bll_2018_124
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.692-700
  • Keywords: breast and colorectal cancers, TRPM2 channel, 5-flourouracil, leucoverin, oxidative stress, OXIDATIVE STRESS, CALCIUM OVERLOAD, APOPTOSIS, MELATONIN, MECHANISMS, TRPV1, CYTOTOXICITY, CHEMOTHERAPY, ACTIVATION
  • Akdeniz University Affiliated: Yes

Abstract

OBJECTIVES: We aimed to reveal the role of 5-fluorouracil (5-FU) and Leucovorin (LV) along with transient receptor potential protein melastatin 2 (TRPM2) channels in breast and colon cancer cells during the treatment process.