Synergic and comparative effect of 5-fluorouracil and leucoverin on breast and colon cancer cells through TRPM2 channels

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Guler Y., Ovey I. S.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.119, sa.11, ss.692-700, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 119 Sayı: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4149/bll_2018_124
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.692-700
  • Anahtar Kelimeler: breast and colorectal cancers, TRPM2 channel, 5-flourouracil, leucoverin, oxidative stress, OXIDATIVE STRESS, CALCIUM OVERLOAD, APOPTOSIS, MELATONIN, MECHANISMS, TRPV1, CYTOTOXICITY, CHEMOTHERAPY, ACTIVATION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

OBJECTIVES: We aimed to reveal the role of 5-fluorouracil (5-FU) and Leucovorin (LV) along with transient receptor potential protein melastatin 2 (TRPM2) channels in breast and colon cancer cells during the treatment process.