Effects of Ticagrelor on Ionic Currents and Contractility in Rat Ventricular Myocytes

KÜÇÜK M., CELEN M. C., YAMASAN B. E., Olgar Y., ÖZDEMİR S.

CARDIOVASCULAR DRUGS AND THERAPY, cilt.29, sa.5, ss.419-424, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s10557-015-6617-2
  • Dergi Adı: CARDIOVASCULAR DRUGS AND THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.419-424
  • Anahtar Kelimeler: Ticagrelor, Ventricular myocytes, L-type Ca2+ currents, Contractility, Action potential, P2Y(12) ANTAGONIST AZD6140, RECEPTOR ANTAGONIST, POTASSIUM CURRENTS, P2 RECEPTORS, ADENOSINE, THIENOPYRIMIDINONES, THIENOPYRIDINES, CLOPIDOGREL, GUINEA, SAFETY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Antiplatelet therapy has been widely used for management of patients with ischaemic heart diseases or thrombotic events. Experimental studies have shown that ticlopidine and clopidogrel decreased L-type Ca2+ currents (I-CaL), altered action potential (AP) duration and thence exerted negative inotropic effects. In this study we tested if ticagrelor, a non-thienopyridine agent, has any influence on contractile and electrical properties of isolated ventricular myocytes.