A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia


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HATIRNAZ NG Ö., Firtina S., Can I., KARAKAŞ Z., Agaoglu L., DOĞRU Ö., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.32, no.2, pp.127-135, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.4274/tjh.2013.0296
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.127-135
  • Keywords: WNT5A, Methylation, Downregulation, Gene expression, ALL, TUMOR-SUPPRESSOR, GROWTH-FACTOR, BETA-CATENIN, HUMAN WNT-5A, EXPRESSION, PROLIFERATION, METHYLATION, PATHWAY, MALIGNANCIES, CARCINOMA
  • Akdeniz University Affiliated: No

Abstract

Objective: WNT5A is one of the most studied noncanonical WNT ligands and is shown to be deregulated in different tumor types. Our aim was to clarify whether hypermethylation might be the cause of low WNT5A mRNA levels and whether we could restore this downregulation by reversing the event.