Akademik Veri Yönetim Sistemi
International Joint Science Congress of Materials and Polymers (ISCMP), Burdur, Türkiye, 29 Eylül - 01 Kasım 2021, ss.48-49
Electrospun
fiber mats have been used for the delivery of hydrophilic/hydrophobic drugs in
drug delivery systems because they offer various properties such as high
surface area/volume ratio, high porosity and high efficiency.1,2 In this study, the electrospun
fibers were prepared by electrospinning polyethylene oxide (PEO),
polymethylmethacrylate (PMMA) blended bis-chalcone derivatives
((2E,6E)‐2,6‐bis[(thiophen‐2‐yl)methylene]cyclohexanone and ((2E,6E)‐2,6‐bis(4-nitrobenzylidene)cyclohexanone),
and streptomycin sulfate as the model drug. The fiber samples were
characterized by scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDX),
Fourier transform infrared spectroscopy (FT-IR), and Thermal gravimetric
analysis (TGA). In vitro release of drug from the drug-loaded fibers was
studied in simulated physiological conditions by ultraviolet-visible
spectroscopy. Morphological analysis results revealed that the electrospun
fibers prepared with the mixture of PMMA, PEO and ((2E,6E)‐2,6‐bis(4-nitrobenzylidene)cyclohexanone)
with streptomycin sulfate had a more uniform, bead-free, and random morphology.
According to the release studies, the highest amount of drug release was
achieved for ((2E,6E)‐2,6‐bis(4-nitrobenzylidene)cyclohexanone) in the 240
minute period. These results showed that drug-loaded PMMA and PEO fiber mats
can be used as drug delivery vehicles in drug delivery systems.