Effects of Different Tacrolimus Doses on Adipose-Derived Stem Cells

ERTOSUN M. G., ÖZKAN Ö., ÖZKAN Ö.

EXPERIMENTAL AND CLINICAL TRANSPLANTATION, cilt.19, sa.7, ss.723-731, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 7
  • Basım Tarihi: 2021
  • Doi Numarası: 10.6002/ect.2019.0325
  • Dergi Adı: EXPERIMENTAL AND CLINICAL TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.723-731
  • Anahtar Kelimeler: Immunosuppression, Rejection, Stem cell pluripotency, Toxicity, PLURIPOTENCY, NANOG, SOX2, EXPRESSION, STRATEGIES, RECIPIENT, REJECTION, SURVIVAL, THERAPY, OCT-3/4
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objectives: Tacrolimus is currently one of the most commonly used immunosuppressant agents to prevent rejection in organ transplant. Although modern immunosuppressive agents have been successful, rejection cannot be completely prevented. Therefore, in organ transplant research, additional treatment methods are being investigated, with the most important one being stem cell therapy. In addition to tacrolimus therapy, stem cell therapy is now clinically applicable, with frequency of concomitant use seeming to expand in the future. In this study, the effects of tacrolimus on stem cells were investigated.