Olanzapine Intoxication-Related Transient Diabetes Insipidus

Kocer E., Alcelik A., Canan F.

RENAL FAILURE, cilt.33, sa.8, ss.842-843, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/0886022x.2011.599094
  • Dergi Adı: RENAL FAILURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.842-843
  • Anahtar Kelimeler: diabetes insipidus, intoxication, olanzapine, suicide, polyuria, OVERDOSE
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Olanzapine is a second-generation atypical antipsychotic agent approved for the treatment of psychotic disorders and mania. The effects of olanzapine intoxication include central nervous system depression, hyperthermia, myosis, tachycardia, and orthostatic hypotension. Heretofore, only one case has been reported to develop polyuria after olanzapine overdose (560 mg). We describe a case that developed diabetes insipidus following massive olanzapine ingestion and returned to normal after desmopressin treatment.