Effect of alpha-lipoic acid on visual evoked potentials in rats exposed to sulfite


DERİN N., Akpinar D., Yargicoglu P., Agar A., Aslan M.

NEUROTOXICOLOGY AND TERATOLOGY, cilt.31, sa.1, ss.34-39, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.ntt.2008.08.002
  • Dergi Adı: NEUROTOXICOLOGY AND TERATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.34-39
  • Anahtar Kelimeler: Alpha-lipoic acid, Oxidative stress, Sulfite, Visual evoked potentials, CHRONIC RESTRAINT STRESS, ANTIOXIDANT ENZYME-ACTIVITIES, LIPID-PEROXIDATION, SULFUR-DIOXIDE, SODIUM METABISULFITE, SUPPLEMENTATION, TOCOPHEROL, TOXICITY, PROPOFOL, LIVER
  • Akdeniz Üniversitesi Adresli: Evet

Özet

This study aimed to investigate the effect of alpha-lipoic acid (LA) administration on sulfite-induced alterations in visual evoked potentials (VEPs). Fifty two male albino Wistar rats were randomized into four experimental groups as follows; control (C), LA treated (L), sodium metabisulfite (Na2S2O5) treated (S), Na2S2O5+LA treated (SL). Na2S2O5 (260 mg/kg/day) and LA (100 mg/kg/day) were given by intragastric intubation for 5 weeks. The latencies of VEP components were significantly prolonged in the S group and returned to control levels following LA administration. Thiobarbituric acid reactive substances (TBARS) levels in the S group were significantly higher than those detected in controls. LA significantly decreased brain and retina TBARS levels in the SL group compared with the S group. Sulfite caused a significant decrease in retina and brain glutathione peroxidase (GPx) activities which was restored to control levels via LA administration. Brain glutathione (GSH):glutathione disulfide (GSSG) ratio was significantly increased in rats jointly treated with sulfite and LA compared to rats treated with sulfite alone. Though not significant, a similar increase in GSH:GSSG ratio was also observed in the retina of SL group. This study showed that LA is protective against sulfite-induced VEP alterations and oxidative stress in the brain and retina. (C) 2008 Elsevier Inc. All rights reserved.