Molecular Diagnosis for Nodal Metastasis in Endoscopically Managed Cervical Cancer: The Accuracy of the APTIMA Test to Detect High-risk Human Papillomavirus Messenger RNA in Sentinel Lymph Nodes

KOEHLER, Christhardt; LE, Xin; Dogan, NASUH; PFİFFER, Tatiana; Schneider, Achim; MARNITZ, Simone; BERTOLINI, Julia; favero, Giovanni

doi:10.1016/j.jmig.2016.03.003

Molecular Diagnosis for Nodal Metastasis in Endoscopically Managed Cervical Cancer: The Accuracy of the APTIMA Test to Detect High-risk Human Papillomavirus Messenger RNA in Sentinel Lymph Nodes

KOEHLER C., LE X., Dogan N. U., PFİFFER T., Schneider A., MARNITZ S., ...More

Journal of Minimally Invasive Gynecology, vol.23, no.5, pp.748-752, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 23 Issue: 5
Publication Date: 2016
Doi Number: 10.1016/j.jmig.2016.03.003
Journal Name: Journal of Minimally Invasive Gynecology
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.748-752
Keywords: Cervical cancer, Endoscopic sentinel node biopsy, Human papillomavirus messenger RNA, Molecular diagnostic, Nodal metastasis, FALSE-NEGATIVE RATE, CARCINOMA, DNA, RECURRENCE, BIOPSY, TUMOR, PCR
Akdeniz University Affiliated: Yes

Abstract

Study Objective: To evaluate the feasibility and accuracy of a commercially available test to detect E6/E7 mRNA of 14 subtypes of high-risk HPVs (APTIMA; Hologic, Bedford, MA) in the sentinel lymph nodes of CC patients laparoscopically operated.