Perceived stress and hair cortisol: Differences in bipolar disorder and schizophrenia

Streit F., Memic A., Hasandedic L., Rietschel L., Frank J., Lang M., ...More

PSYCHONEUROENDOCRINOLOGY, vol.69, pp.26-34, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69
  • Publication Date: 2016
  • Doi Number: 10.1016/j.psyneuen.2016.03.010
  • Journal Name: PSYCHONEUROENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.26-34
  • Keywords: Bipolar disorder, Schizophrenia, Hair cortisol, Perceived stress, Genetic risk, PITUITARY-ADRENAL AXIS, LIFE EVENTS, PSYCHOSOCIAL STRESS, HPA AXIS, HIGH-RISK, SOCIAL STRESS, 1ST EPISODE, INDIVIDUALS, RESPONSES, METAANALYSIS
  • Akdeniz University Affiliated: No

Abstract

Introduction: Bipolar disorder (BD) and schizophrenia (SCZ) are psychiatric disorders with shared and distinct clinical and genetic features. In both disorders, stress increases the risk for onset or relapse and dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis has been reported. The latter is frequently investigated by measuring changes in the hormonal end product of the HPA axis, i.e., the glucocorticoid cortisol, whose concentration exhibits diurnal variation. The analysis of hair cortisol concentration (HCC) is a new method, which allows assessment of cumulative cortisol secretion over the preceding three months.