The effect of pressure-and volume-controlled one-lung ventilation on lung dynamics and plasma malondialdehyde level

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Yavuz O., KABUKÇU H., Sahin N., ÖZDEM S., ERDOĞAN A., TİTİZ T.

JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE, cilt.10, sa.3, ss.325-329, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4328/jcam.5884
  • Dergi Adı: JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), EMBASE
  • Sayfa Sayıları: ss.325-329
  • Anahtar Kelimeler: One-lung Ventilation, Pressure-Controlled Ventilation, Volume-Controlled Ventilation, Malondialdehyde, Lipid Peroxidation, MANAGEMENT, SURGERY, INJURY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Aim: The main purpose of the study was to assess the effects of modes of volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) during one-lung ventilation (OLV) on serum malondialdehyde (MDA), which is the end product of lipid peroxidation. Arterial blood gases, respiratory dynamics, and hemodynamic values were also comparatively investigated. Material and Method: This study is a single-center, prospective, randomized, controlled clinical study was conducted in the Single-center, Thoracic Surgery Operating Room of University Faculty of Medicine. Patients were randomly divided into two groups: Group P (pressure controlled, 20 cases) and Group V (volume-controlled, 20 cases). Following induction, a double-lumen endotracheal tube was placed. Hemodynamics and respiratory parameters were recorded during the operation. For MDA measurements. arterial blood specimens were taken just before the operation (preoperative), after OLV, and 6 hours after the operation. Results: The values of hemodynamics were similar in both groups. Serum MDA measurements were found similar in both groups at preoperative, end of OLV and 6 hours after the operation. Discussion: During OLV the effects of PCV and VCV on plasma MDA levels are not different from each other. Therefore we are of the opinion that selection of PCV or VCV as respiratory mode created no significant differences in oxidative stress.