Prenatal management, pregnancy and pediatric outcomes in fetuses with septated cystic hygroma

Creative Commons License

SANHAL C. Y., MENDİLCİOĞLU İ. İ., Ozekinci M., Yakut S., Merdun Z., ŞİMŞEK M., ...Daha Fazla

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, cilt.47, sa.9, ss.799-803, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 9
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1590/1414-431x20143895
  • Dergi Adı: BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.799-803
  • Anahtar Kelimeler: Septated, Cystic, Hygroma, Perinatal, Outcomes, Neurologic, CHROMOSOMAL MICROARRAY, NUCHAL-TRANSLUCENCY, 1ST-TRIMESTER, DIAGNOSIS, ULTRASOUND, ANOMALIES, ABNORMALITIES, GESTATION, PROGNOSIS, LESIONS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

It has been reported that, compared with simple increased nuchal translucency, fetal cases with septated cystic hygroma (CH) are more likely to face perinatal handicaps. However, pediatric outcomes and proper prenatal counseling for this anomaly have not yet been truly defined. We performed this study to determine pregnancy and pediatric outcomes of fetuses with septated CH. We searched records for cases with septated CH and collected data for structural abnormalities, karyotype analysis, and pregnancy outcomes. Fetuses born with septated CH were also evaluated for their pediatric outcomes. Sixty-nine fetuses with septated CH were enrolled in the study. Results showed that chromosomal abnormalities were present in 28 fetuses (40.6%), and the most common aneuploidy was Turner syndrome (n = 14, 20.3%); 16 (23.2%) of the remaining cases, in which aneuploidy was not found, had coexistent structural malformations; 25 (36.2%) cases had normal karyotype and morphology. The total number of live births and infants with unfavorable neurologic follow-up were 13 (18.8%) and 2 (2.9%), respectively. Septated CH is associated with poor perinatal outcomes; therefore, karyotype analysis and ultrasonographic anomaly screening should be performed as initial steps, and expectant management should be offered to couples with euploid fetuses that have normal morphology.