Effects of swimming exercise on red blood cell rheology in trained and untrained rats

Yalcin O., Bor-Kucukatay M., Senturk U., Baskurt O.

JOURNAL OF APPLIED PHYSIOLOGY, vol.88, no.6, pp.2074-2080, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 88 Issue: 6
  • Publication Date: 2000
  • Doi Number: 10.1152/jappl.2000.88.6.2074
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2074-2080
  • Keywords: hemorheology, erythrocyte deformability, erythrocyte aggregation, oxidant stress, PHYSICAL-ACTIVITY, SUPEROXIDE ANIONS, AGGREGATION, DEFORMABILITY, FLOW, RELEVANCE, CAPACITY, MEMBRANE, LACTATE, FITNESS
  • Akdeniz University Affiliated: No


Red blood cell (RBC) mechanical properties were investigated after swimming exercise in trained and untrained rats. A group of rats was trained for 6 wk (60 min swimming, daily), and another group was kept sedentary. Blood samples were obtained either within 5 min or 24 h after 60 min swimming in both groups. In the untrained rats, the RBC aggregation index decreased to 2.60 +/- 0.4 immediately after exercise from a control value of 6.73 +/- 0.18 (P < 0.01), whereas it increased to 13.13 +/- 0.66 after 24 h (P < 0.01). RBC transit time through 5-mu m pores increased to 3.53 +/- 0.16 ms within 5 min after the exercise from a control value of 2.19 +/- 0.07 ms (P < 0.005). A very significant enhancement (166%) in RBC lipid peroxidation was detected only after 24 h. In the trained group, the alterations in all these parameters were attenuated; there was a slight, transient impairment in RBC deformability (transit time = 2.64 +/- 0.13 ms), and lipid peroxidation was found to be unchanged. These findings suggest that training can significantly limit the hemorheological alterations related to a given bout of exercise. Whether this effect is secondary to the training-induced reduction in the degree of metabolic and/or hormonal perturbation remains to be determined.