Short-term effects of cilazapril and atenolol on P-wave dispersion in patients with hypertension
ADVANCES IN THERAPY, vol.25, no.2, pp.99-105, 2008 (SCI-Expanded)
- Publication Type: Article / Article
- Volume: 25 Issue: 2
- Publication Date: 2008
- Doi Number: 10.1007/s12325-008-0012-3
- Journal Name: ADVANCES IN THERAPY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.99-105
- Keywords: atenolol, cilazapril, P-wave dispersion, CONVERTING-ENZYME-INHIBITION, CONGESTIVE-HEART-FAILURE, ATRIAL-FIBRILLATION, RANDOMIZED-TRIAL, ANGIOTENSIN-II, DURATION, HYPERTROPHY, MORBIDITY, MORTALITY, PRESSURE
- Akdeniz University Affiliated: Yes
Abstract
Introduction: P-wave dispersion ( PWD) has been shown to be a non-invasive electrocardiographic predictor for development of atrial fibrillation ( AF). Thus, it may be possible to decrease AF risk through improvement in PWD. Our objective was to compare the effects of cilazapril and atenolol on P-wave duration and dispersion in patients with hypertension.
Methods: A total of 38 newly diagnosed hypertensive patients were enrolled in the study. The patients were randomly assigned to receive treatment with either cilazapril ( 5 mg) or atenolol ( 50 mg). Doppler echocardiographic examination, P-wave durations and PWD were measured before and 1 mo after treatment
Results: Both drugs reduced blood pressure significantly ( P< 0.001). Post-treatment heart rate was significantly lower in the atenolol group ( P= 0.01). The change in maximum P-wave duration was not significant. However, both agents decreased PWD ( P= 0.001 and P< 0.001) and increased the minimum P-wave duration ( P= 0.004 and P= 0.02).
Conclusion: Both cilazapril and atenolol treatments resulted in improvement in PWD.