Early Changes in Carcinogenesis of Colorectal Adenomas

TORU H. S., Bilezikci B.

WEST INDIAN MEDICAL JOURNAL, vol.61, no.1, pp.10-16, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.7727/wimj.2011.136
  • Journal Name: WEST INDIAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.10-16
  • Keywords: Adenomatous polyps, carcinogenesis, HPV, HUMAN-PAPILLOMAVIRUS INFECTION, COLON-CANCER, CYCLIN D1, GENE-MUTATIONS, E-CADHERIN, EXPRESSION, CARCINOMA, P53, BCL-2, HPV
  • Akdeniz University Affiliated: Yes

Abstract

Objectives: Adenocarcinoma of the colon and rectum is the third most common cause of cancer deaths and the sixth most common cancer in the world. Adenomas are benign neoplastic lesions which can be transformed into carcinomas, but this is usually not the case. There should be some risk factors which lead to the development of carcinomas into adenomas. The aim of this study is to find out the early changes and high risk factors related to carcinogenesis in colonic polyps.