Akademik Veri Yönetim Sistemi
NATO Advanced Research Workshop on Frontiers in Neurodegenerative Disorders and Aging, Antalya, Türkiye, 27 Mayıs - 01 Haziran 2003, cilt.358, ss.158-169
Neurodegenerative disorders, which are chronic and progressive, are characterized by :elective and symmetric loss of neurons in motor, sensory, or cognitive systems. The most important risk factors for neurodegenerative diseases are old age and a positive family history. In addition to the possible involvement of aging, oxidative damage may also play an important role in the slowly progressive neuronal death that is characteristic of several neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease. These diseases of the brain are thought to involve oxidative processes either as a primary cause or as a consequence of disease progression. This review discusses the role of reactive oxygen species in the pathogenesis of neurodegenerative diseases and examines the relevance of antioxidant therapy in preventing neurodegeneration.