Akademik Veri Yönetim Sistemi
Nanosafety, Ernesto Alfaro-Moreno Fiona Murphy, Editör, Springer Nature, Chur, ss.337-363, 2025
Nanoparticles are increasingly integrated to advancements in technology, medicine, and environmental science, offering unique properties that enhance drug delivery systems, diagnostic methods, and material efficiency. However, the widespread use of nanoparticles also raises concerns regarding their potential toxicity and environmental impact. Addressing these concerns necessitates robust safety assessments and a comprehensive understanding of nanoparticle interactions within biological systems. Drosophila melanogaster, commonly known as the fruit fly, serves as an invaluable model for studying the biological implications of nanoparticles. Its well-documented genetic background, short life cycle, and biological similarities to mammals make it ideal for evaluating nanoparticle toxicity. This chapter explores the role of Drosophila in nanoparticle research, particularly in assessing safety and elucidating the mechanisms of nanoparticle interaction at the cellular and behavioral levels. Studies using Drosophila have demonstrated that nanoparticles can induce genetic, cellular, and behavioral changes, which vary depending on the composition, size, shape, and exposure level of the nanoparticle. These findings highlight the necessity of safety assessments and the development of standardized testing protocols. In conclusion, as nanoparticles use become more prevalent across multiple sectors, the importance of rigorous safety evaluations grows. Using Drosophila for these assessments not only deepens our understanding of nanoparticle toxicity but also supports the development of safer nanotechnologies.