Evaluation of Oxidative Stress Parameters and Urinary Deoxypyridinoline Levels in Geriatric Patients with Osteoporosis

Creative Commons License

Demir M., Ulas T., Tutoglu A., Boyaci A., Karakas E. Y., Sezen H., ...Daha Fazla

JOURNAL OF PHYSICAL THERAPY SCIENCE, cilt.26, sa.9, ss.1405-1409, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 9
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1589/jpts.26.1405
  • Dergi Adı: JOURNAL OF PHYSICAL THERAPY SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1405-1409
  • Anahtar Kelimeler: Osteoporosis, Oxidative stress index, Deoxypyridinoline, BONE-MINERAL DENSITY, VITAMIN-D STATUS, POSTMENOPAUSAL WOMEN, NITRIC-OXIDE, CRUCIAL ROLE, ANTIOXIDANTS, METABOLISM, TURNOVER, MARKERS
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

[Purpose] To evaluate the oxidative stress parameters and urinary deoxypyridinoline levels in geriatric patients with osteoporosis. [Subjects and Methods] Eighty geriatric patients aged over 65 years were recruited. Patients were divided into two groups: Group 1 (n=40) consisted of patients with osteoporosis, and Group 2 (n=40) consisted of patients without osteoporosis. Bone mineral density measurements were performed for all patients using DEXA. Oxidative stress parameters were analyzed in blood samples, and deoxypyridinoline levels were analyzed in 24-hour urinary samples. [Results] Compared to Group 2, the total antioxidant status and oxidative stress index levels of Group 1 were not significantly different; however, total oxidant status and 24-hour urinary deoxypyridinoline levels were significantly higher. Pearson correlation coefficients indicated that OSI and urinary deoxypyridinoline levels were not correlated with any biochemical parameters. ROC-curve analysis revealed that urinary deoxypyridinoline levels over 30.80 mg/ml predicted osteoporosis with 67% sensitivity and 68% specificity (area under the curve = 0.734; %95 CI: 0.624-0.844). [Conclusion] Our results indicate that oxidative stress would play a role in the pathogenesis of osteoporosis, and that urinary deoxypyridinoline levels may be a useful screening test for osteoporosis.