Next step in 2nd generation glucose biosensors: Ferrocene-loaded electrospun nanofibers

Guven N., Apetrei R., ÇAMURLU P.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, cilt.128, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 128
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.msec.2021.112270
  • Dergi Adı: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Biotechnology Research Abstracts, Chemical Abstracts Core, Communication Abstracts, Compendex, EMBASE, INSPEC, MEDLINE, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: Polyacrylonitrile, Ferrocene, Carbon nanotubes, Electrospun nanofibers, Glucose biosensors, CARBON NANOTUBES, AMPEROMETRIC BIOSENSORS, OXIDASE, CONSTRUCTION, MEDIATOR, FILM
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Glucose determination is one of the most common analyses in clinical chemistry. Employing biosensors for this purpose has become the method of choice for home use for diabetic patients. To limit the impact of dissolved O-2 concentration or possible interferences (known hindrances in the classical glucose detection approach), a variety of mediated pathways have been explored. Herein, an ingenious, facile and low-cost approach for immobilization of redox mediator within nanofibrous mats is presented. This '2nd generation' biosensor is able to avoid common issues such as leaching or diffusion barriers whilst providing the necessary close contact between the enzyme and the redox shuttle, for enhancing the detection accuracy and accelerate the response.