The Evaluation of Hypoxia-Inducible Factor 1 in N-Nitro-L-Arginine Methyl Ester Preeclampsia Model of Pregnant Rats

Kaya A., Boztosun A., SECKIN H., GUVEN A. S., Kucukdurmaz Z., Gulturk S., ...More

JOURNAL OF INVESTIGATIVE MEDICINE, vol.59, no.8, pp.1268-1272, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.2310/jim.0b013e31822fff4a
  • Journal Name: JOURNAL OF INVESTIGATIVE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1268-1272
  • Keywords: hypoxia-inducible factor 1, preeclampsia, rat, SOLUBLE ENDOGLIN, OXIDE SYNTHESIS, BLOOD-PRESSURE, GROWTH-FACTOR, PLASMA-LEVELS, HYPERTENSION, EXPRESSION, PATHWAYS, BLOCKADE, SYNTHASE
  • Akdeniz University Affiliated: No

Abstract

Objective: The objective of the study was to evaluate hypoxia-inducible factor 1 (HIF-1), which plays a major role in the stimulation of angiogenesis in placental tissues, by using immunohistochemical staining in preeclampsia model of rats, developed by N-nitro-L-arginine methyl ester (L-NAME)