Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy

Hamann, Lutz; Kumpf, Oliver; Schuring, Ron; ALPSOY, ERKAN; Bedu-Addo, George; Bienzle, Ulrich; Oskam, Linda; Mockenhaupt, Frank; Schumann, Ralf

doi:10.1186/1471-2350-10-65

Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy

Hamann L., Kumpf O., Schuring R. P., ALPSOY E., Bedu-Addo G., Bienzle U., ...Daha Fazla

BMC MEDICAL GENETICS, cilt.10, 2009 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 10
Basım Tarihi: 2009
Doi Numarası: 10.1186/1471-2350-10-65
Dergi Adı: BMC MEDICAL GENETICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Akdeniz Üniversitesi Adresli: Evet

Özet

Background: The Toll-like receptors (TLRs) mediate innate immunity to various pathogens. A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be common in Europeans and Africans and to roughly half the risks of heterogeneous infectious diseases including malaria, tuberculosis, bacteremia, and invasive pneumococal disease in heterozygous mutation carriers.