The effect of the sun on expression of beta-catenin, p16 and cyclin d1 proteins in melanocytic lesions

Demirkan N. C., Kesen Z., Akdag B., Larue L., Delmas V.

CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol.32, no.6, pp.733-739, 2007 (SCI-Expanded) identifier identifier identifier


Background. The tumour suppressor gene product, p16, is often inactivated during melanoma malignant progression. Although the importance of p16 in melanomas is well documented, its relationship with cyclin D1, beta-catenin and ultraviolet radiation (UVR) remains unclear.