Deformability and oxidant stress in red blood cells under the influence of halothane and isoflurane anesthesia

Yesilkaya A., Ertug Z., Yegin A., Melikoglu M., Baskurt O.

GENERAL PHARMACOLOGY, cilt.31, sa.1, ss.33-36, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 1
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1016/s0306-3623(97)00426-6
  • Dergi Adı: GENERAL PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.33-36
  • Anahtar Kelimeler: halothane, isoflurane, red blood cell deformability, hemorheology, oxidant stress, lipid peroxidation, INDUCTION, HEPATOTOXICITY, AUTOXIDATION, TOXICITY, INVIVO, RABBIT, LIVER, FLOW, RATS
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

1. The effects of halothane and isoflurane anesthesia on red blood cell (RBC) deformability, lipid peroxidation and antioxidant enzymes were tested in rabbits.
Abstract

1. The effects of halothane and isoflurane anesthesia on red blood cell (RBC) deformability, lipid peroxidation and antioxidant enzymes were tested in rabbits.

2. RBC transit time was significantly increased to 2.12+/-0.07 msec after 1-hr halothane anesthesia preceded by 6 mg/kg pentobarbital injections from 1.98+/-0.07 msec preanesthesia value (p<0.05). Thiobarbituric acid-reactive substances also were increased significantly, being 23.35+/-2.75 nmol/gHb and 33.11+/-5.34 nmol/gHb before and after anesthesia, respectively (p<0.05).

3. Under halothane anesthesia without prior pentobarbital injection or under isoflurane anesthesia with or without pentobarbital injection, no significant alterations were observed in these parameters.

4. RBC superoxide dismutase activity was decreased in the group anesthetized with the pentobarbital-halothane combination. The impaired RBC deformability and increased oxidant damage might be related to the free radical formation during the metabolism of halothane. Pentobarbital can potentiate this effect either by inducing cytochrome P-450 or by altering antioxidant defense.

5. Alterations in RBC mechanical properties may contribute to the tissue perfusion problems that develop after surgery under general anesthesia. (C) 1998 Elsevier Science Inc.