Akademik Veri Yönetim Sistemi
MARMARA MEDICAL JOURNAL, cilt.29, sa.3, ss.181-184, 2016 (ESCI)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are found in the liver in their highest concentrations. Two most common causes of asymptomatic transaminase elevation are viral infections and alcohol intake. Persistent non-viral non-alcohol related elevation of aminotransferases indicates that one or both aminotransferase levels exceed the upper reference limit for a period of at least 4 weeks. Causes are classified as hepatic; such as steatosis, autoimmune hepatitis, Wilson's disease, hemachromatosis, and nonhepatic; such as celiac disease, myopathy and hyperthyroidism. Drug use and substance abuse may also cause an increase in aminotransferase levels. Here, we report a fifty-eight-year old female patient who had asymptomatic non-viral non-alcohol related aminotransferase elevation for a year incidentally diagnosed with malignant infiltration of the liver. It should be noted that, malignant infiltration of the liver may also be a rare cause of asymptomatic persistent elevation of transaminases. Such cases, especially with suspected malignancy should be evaluated in terms of this condition.