Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.35, sa.4, ss.209-217, 2015 (SCI-Expanded)
© 2015 by Türkiye Klinikleri.Objective: Clomiphene citrate (CC) a nonsteroidal tissue selective estrogen receptor modulator is used for inducing ovulation. In this study, we aimed to investigate the histopathological changes and dose related effects of long term CC treatment on rat ovary and endometrium. Material and Methods: Four groups of female rats were included in the study. In group 1 (control) only saline was administered whereas in groups 2, 3 and 4 CC was (once a week) administered for 18 weeks at the doses of 1 mg/kg, 4 mg/kg and 8 mg/kg, respectively. Uterus and both ovaries were excised for histopathological evaluation. Results: Histopathological examination showed that papillary hyperplasia of the surface epithelium of the ovary was present in all CC treated groups, with the highest percentage and severity in group 4. The mean values of endometrial thickness and en-dometrial gland diameters in this group were lower than those in groups 1 and 2 (p<0.05). Diameters of ovaries and ovarian surface epithelium in group 4 were decreased with respect to control group (p<0.05). Conclusion: High doses and repetitive treatment with CC may have detrimental effects in terms of endometrial thinning and developing precancerous lesions in the ovaries.