Decreased Paraoxonase 1, Arylesterase Enzyme Activity, and Enhanced Oxidative Stress in Patients with Mitral and Aortic Valve Insufficiency

Yilmaz N., Simsek N., Aydin O., Yardan E., Aslan S., Eren E., ...Daha Fazla

CLINICAL LABORATORY, cilt.59, sa.5-6, ss.597-604, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 5-6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.7754/clin.lab.2012.120629
  • Dergi Adı: CLINICAL LABORATORY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.597-604
  • Anahtar Kelimeler: heart valve disease, oxidant, antioxidant, paraoxonase, arylesterase, oxidative stress, DENSITY-LIPOPROTEIN, REGURGITATION, EXPRESSION, PRESERVES, DISEASE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Oxidative stress is reportedly associated with several cardiovascular diseases. The antioxidant ability of high density lipoprotein (HDL) is, at least in part, attributable to the pleiotropic serum paraoxonase (PON1). The aim of the study was to investigate the body oxidant/antioxidant balance in patients with mitral regurgitation (MR) and aortic regurgitation (AR) to get new points of view for the underlying oxidative mechanisms.