Decreased Paraoxonase 1, Arylesterase Enzyme Activity, and Enhanced Oxidative Stress in Patients with Mitral and Aortic Valve Insufficiency

Yilmaz N., Simsek N., Aydin O., Yardan E., Aslan S., Eren E., ...More

CLINICAL LABORATORY, vol.59, no.5-6, pp.597-604, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 5-6
  • Publication Date: 2013
  • Doi Number: 10.7754/clin.lab.2012.120629
  • Journal Name: CLINICAL LABORATORY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.597-604
  • Keywords: heart valve disease, oxidant, antioxidant, paraoxonase, arylesterase, oxidative stress, DENSITY-LIPOPROTEIN, REGURGITATION, EXPRESSION, PRESERVES, DISEASE
  • Akdeniz University Affiliated: Yes

Abstract

Background: Oxidative stress is reportedly associated with several cardiovascular diseases. The antioxidant ability of high density lipoprotein (HDL) is, at least in part, attributable to the pleiotropic serum paraoxonase (PON1). The aim of the study was to investigate the body oxidant/antioxidant balance in patients with mitral regurgitation (MR) and aortic regurgitation (AR) to get new points of view for the underlying oxidative mechanisms.