Decreased Paraoxonase 1, Arylesterase Enzyme Activity, and Enhanced Oxidative Stress in Patients with Mitral and Aortic Valve Insufficiency

Yilmaz, Necat; Simsek, Nevin; Aydin, Ozgur; Yardan, Emirivin; Aslan, Sakir; Eren, Esin; Yegin, Aysenur; Buyukas, Sadik

doi:10.7754/clin.lab.2012.120629

Decreased Paraoxonase 1, Arylesterase Enzyme Activity, and Enhanced Oxidative Stress in Patients with Mitral and Aortic Valve Insufficiency

Yilmaz N., Simsek N., Aydin O., Yardan E., Aslan S., Eren E., ...Daha Fazla

CLINICAL LABORATORY, cilt.59, sa.5-6, ss.597-604, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 59 Sayı: 5-6
Basım Tarihi: 2013
Doi Numarası: 10.7754/clin.lab.2012.120629
Dergi Adı: CLINICAL LABORATORY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.597-604
Anahtar Kelimeler: heart valve disease, oxidant, antioxidant, paraoxonase, arylesterase, oxidative stress, DENSITY-LIPOPROTEIN, REGURGITATION, EXPRESSION, PRESERVES, DISEASE
Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Oxidative stress is reportedly associated with several cardiovascular diseases. The antioxidant ability of high density lipoprotein (HDL) is, at least in part, attributable to the pleiotropic serum paraoxonase (PON1). The aim of the study was to investigate the body oxidant/antioxidant balance in patients with mitral regurgitation (MR) and aortic regurgitation (AR) to get new points of view for the underlying oxidative mechanisms.