Optical measurement of photosensitizer concentration using a probe with a small source-detector fiber separation

Canpolat M., Mourant J.

Conference on Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II, San-Jose, Costa Rica, 25 - 26 January 2000, vol.3911, pp.10-18 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume: 3911
  • Doi Number: 10.1117/12.384915
  • City: San-Jose
  • Country: Costa Rica
  • Page Numbers: pp.10-18
  • Keywords: photodynamic therapy, photosensitizer concentration, minimally invasive measurements, OPTIMIZING LIGHT DOSIMETRY, FLUORESCENCE SPECTROSCOPY, PHOTODYNAMIC THERAPY, SPECTRA, TISSUE, MEDIA
  • Akdeniz University Affiliated: No

Abstract

We present a novel minimally invasive method to measure the concentration of photodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescence Light using a steady state fluorescence spectrometer. The ratio of the fluorescence to scattered light is found to be linearly proportional to the absorption coefficient of the photosensitizer. The fiber-optic probe used for the measurements has a small source-detector separation, therefore the measurements could be performed through the working channel of an endoscope.