The effect of intraabdominal pressure and carbon dioxide on tissue oxygenation
6th World Congress of Endoscopic Surgery, Rome, Italy, 3 - 06 June 1998
- Publication Type: Conference Paper / Full Text
- City: Rome
- Country: Italy
- Akdeniz University Affiliated: No
Abstract
The increase of intraabdominal pressure (IAP) due to CO2 insufflation during Laparoscopic surgery has became a widely used procedure in the recent years. The goal of this study was to investigate the effects of CO2 and elevated IAP on oxyhemoglobin dissociation curve (OHDC) and tissue oxygenation. Three groups of quines pigs were used for the experiments. Group 1 as control, group 2 saline to increase the IAP, group 3 CO2 to increase the IAP. It was observed to be a marked shift of OHDC in group 3, comparing to groups 1 and 2. The decreased of A-V PO2 was significant in group 3 comparing to group 1 and group 2, Thiobarbituric acid reducing substances (TBARS) were elevated in group 3 significantly comparing to groups 1 and 2. Alanin transferase (ALT) and aspartat transferase (AST) elevations were also significant in group 3 comparing to the other groups. These results show that oxygen was not used adequately in the tissues of CO2 insufflation group and there might also be a free radical injury in this group. Therefore we conclude that CO2 pneumonperitoneum is a cause of oxydative stress an the tissues.