The effects of iloprost and vitamin C on kidney as a remote organ after ischemia/reperfusion of lower extremities

Ozcan A. V., Sacar M., Aybek H., Bir F., Demir S., Onem G., ...More

JOURNAL OF SURGICAL RESEARCH, vol.140, no.1, pp.20-26, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 140 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jss.2006.04.031
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.20-26
  • Keywords: ischemia/reperfusion, remote organ damage, kidney injury, iloprost, vitamin C, ISCHEMIA-REPERFUSION INJURY, ACUTE LUNG INJURY, SKELETAL-MUSCLE, ASCORBIC-ACID, HEPATIC ISCHEMIA/REPERFUSION, TISSUE-DAMAGE, CELL-ADHESION, NITRIC-OXIDE, SPINAL-CORD, PROSTACYCLIN
  • Akdeniz University Affiliated: No

Abstract

Background. Abdominal aortic surgery can cause ischemic/reperfusion (I/R) injury in not only the lower extremities, but also in the remote organs and tissues such as lungs, kidneys, heart, and liver during abdominal aortic surgery. It can result in mortality and morbidity because of the remote organ injury in early postoperative period. In this study, we investigate the effects of iloprost and vitamin C on the kidney remote organ damage after I/R following abdominal aortic surgery.