The effects of iloprost and vitamin C on kidney as a remote organ after ischemia/reperfusion of lower extremities

Ozcan, Ali; Sacar, Mustafa; Aybek, Hulya; Bir, Ferda; Demir, Suleyman; Onem, Gokhan; Goksin, Ibrahim; Baltalarli, Ahmet; Colakoglu, Nagihan

doi:10.1016/j.jss.2006.04.031

The effects of iloprost and vitamin C on kidney as a remote organ after ischemia/reperfusion of lower extremities

Ozcan A. V., Sacar M., Aybek H., Bir F., Demir S., Onem G., ...More

JOURNAL OF SURGICAL RESEARCH, vol.140, no.1, pp.20-26, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 140 Issue: 1
Publication Date: 2007
Doi Number: 10.1016/j.jss.2006.04.031
Journal Name: JOURNAL OF SURGICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.20-26
Keywords: ischemia/reperfusion, remote organ damage, kidney injury, iloprost, vitamin C, ISCHEMIA-REPERFUSION INJURY, ACUTE LUNG INJURY, SKELETAL-MUSCLE, ASCORBIC-ACID, HEPATIC ISCHEMIA/REPERFUSION, TISSUE-DAMAGE, CELL-ADHESION, NITRIC-OXIDE, SPINAL-CORD, PROSTACYCLIN
Akdeniz University Affiliated: No

Abstract

Background. Abdominal aortic surgery can cause ischemic/reperfusion (I/R) injury in not only the lower extremities, but also in the remote organs and tissues such as lungs, kidneys, heart, and liver during abdominal aortic surgery. It can result in mortality and morbidity because of the remote organ injury in early postoperative period. In this study, we investigate the effects of iloprost and vitamin C on the kidney remote organ damage after I/R following abdominal aortic surgery.