Protective effects of syringic acid on neurobehavioral deficits and hippocampal tissue damages induced by sub-chronic deltamethrin exposure.

Ogut E., ŞEKERCİ R., Akcay G., YILDIRIM F. B., DERİN N., Aslan M., ...More

Neurotoxicology and teratology, vol.76, pp.106839, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76
  • Publication Date: 2019
  • Doi Number: 10.1016/j.ntt.2019.106839
  • Journal Name: Neurotoxicology and teratology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.106839
  • Keywords: Sub-chronic deltamethrin exposure, Hippocampus, Syringic acid, Syringic acid administration, Syringic acid treatment, OXIDATIVE STRESS, PYRETHROID INSECTICIDES, MORUS-NIGRA, ANTIOXIDANT, RAT, INJURY, CHANNELS, PARAMETERS, TOXICITY, BEHAVIOR
  • Akdeniz University Affiliated: Yes

Abstract

Recent developments in the field of insecticide exposure have led to a renewed interest in alternative antioxidant therapy. The present study was to investigate the neuroprotective role of syringic acid (SA, 25 mg/kg/day) on the neurotoxicity and oxidative damage induced by deltamethrin (DTM, 1.28 mg/kg/day during two months) in CA1/3 pyramidal neurons. Animals were divided into 4 groups (n = 16/group) (250-270 g) for control, DTM, SA and DTM + SA. DTM and SA were administered by oral gavage daily. Rats that were given sub-chronic DTM had revealed a significant increase in caspase-3 levels, impaired recognition memory, reduced antioxidant activity and enhanced free radicals in the hippocampus. The results showed that SA ameliorated neurobehavioral alterations, reduced reactive oxygen/nitrogen species, pyknosis in the CA1/3 and increased antioxidant enzyme activity. In conclusion, SA (25 mg/kg/day) had potential neuroprotective and therapeutic impacts against sub-chronic DTM exposure via its antioxidant and antiapoptotic efficacy. Therefore, it can be used as a neuroprotective natural plant-derived agent against DTM-induced neurotoxicity.