Effect of doxazosin on expression of eNOS in rat kidney in the presence of partial bladder outlet obstruction

Kutlu O., YALCINKAYA M., KUTLU S., ELPEK G. Ö., KÖKSAL İ. T., KUKUL E.

JOURNAL OF NEPHROLOGY, vol.25, no.5, pp.750-754, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.5301/jn.5000055
  • Journal Name: JOURNAL OF NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.750-754
  • Keywords: Doxazosin, eNOS, Immunohistochemistry, Kidney, NITRIC-OXIDE SYNTHASE, MESANGIAL CELLS, RENAL INJURY, NEPHROPATHY, FIBROSIS
  • Akdeniz University Affiliated: Yes

Abstract

Background: The role of nitric oxide in the pathogenesis of renal injury has begun to be appreciated. We therefore designed this study to demonstrate the relationship between endothelial nitric oxide synthase (eNOS) expression and doxazosin in the kidneys of rats with surgically created partial bladder outlet obstruction (BOO), to further understand the role of doxazosin in the prevention of renal parenchymal damage by partial BOO.