Chronic toxicity of pesticides to the mRNA expression levels of metallothioneins and cytochrome P450 1A genes in rainbow trout


Creative Commons License

Ceyhun S. B., Aksakal E., Kirim B., Atabeyoglu K., Erdoğan O.

TOXICOLOGY AND INDUSTRIAL HEALTH, vol.28, no.2, pp.162-169, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1177/0748233711409482
  • Journal Name: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.162-169
  • Keywords: MTs, CYP-450, deltamethrin, DDVP, Oncorhynchus mykiss, FLOUNDER PLATICHTHYS-FLESUS, OXIDATIVE STRESS, IN-VITRO, ONCORHYNCHUS-MYKISS, CARBONIC-ANHYDRASE, AH RECEPTOR, DNA-DAMAGE, INDUCTION, LIVER, ERYTHROCYTES
  • Akdeniz University Affiliated: No

Abstract

The hazardous effects of pesticides on various metabolic pathways are a great problem for environmental health and should be well determined. In the present study, the authors treated rainbow trout with 0.6 mu g/L deltamethrin for 28 days and 1.6 mg/L 2,2-dichlorovinyl dimethyl phosphate for 21 days. After this time period, the authors observed alterations in mRNA expression levels of MT-A, MT-B and CYP-1A. Chronic exposure to low levels of pesticides may have a more significant effect on fish populations than acute poisoning. While both pesticides caused a significant increase on mRNA levels of MT-A and CYP-1A, MT-B mRNA levels were increased significantly only upon deltamethin administration. The significant increase in mRNA levels of the corresponding genes may be considered as a defence mechanism in addition to the antioxidants against oxidative stress, as well as a detoxification mechanism against adverse effects of pesticides.