Chronic toxicity of pesticides to the mRNA expression levels of metallothioneins and cytochrome P450 1A genes in rainbow trout

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Ceyhun S. B., Aksakal E., Kirim B., Atabeyoglu K., Erdoğan O.

TOXICOLOGY AND INDUSTRIAL HEALTH, vol.28, no.2, pp.162-169, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1177/0748233711409482
  • Journal Name: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.162-169
  • Keywords: MTs, CYP-450, deltamethrin, DDVP, Oncorhynchus mykiss, FLOUNDER PLATICHTHYS-FLESUS, OXIDATIVE STRESS, IN-VITRO, ONCORHYNCHUS-MYKISS, CARBONIC-ANHYDRASE, AH RECEPTOR, DNA-DAMAGE, INDUCTION, LIVER, ERYTHROCYTES
  • Akdeniz University Affiliated: No

Abstract

The hazardous effects of pesticides on various metabolic pathways are a great problem for environmental health and should be well determined. In the present study, the authors treated rainbow trout with 0.6 mu g/L deltamethrin for 28 days and 1.6 mg/L 2,2-dichlorovinyl dimethyl phosphate for 21 days. After this time period, the authors observed alterations in mRNA expression levels of MT-A, MT-B and CYP-1A. Chronic exposure to low levels of pesticides may have a more significant effect on fish populations than acute poisoning. While both pesticides caused a significant increase on mRNA levels of MT-A and CYP-1A, MT-B mRNA levels were increased significantly only upon deltamethin administration. The significant increase in mRNA levels of the corresponding genes may be considered as a defence mechanism in addition to the antioxidants against oxidative stress, as well as a detoxification mechanism against adverse effects of pesticides.