Chronic toxicity of pesticides to the mRNA expression levels of metallothioneins and cytochrome P450 1A genes in rainbow trout
TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.28, sa.2, ss.162-169, 2012 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 2
- Basım Tarihi: 2012
- Doi Numarası: 10.1177/0748233711409482
- Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.162-169
- Anahtar Kelimeler: MTs, CYP-450, deltamethrin, DDVP, Oncorhynchus mykiss, FLOUNDER PLATICHTHYS-FLESUS, OXIDATIVE STRESS, IN-VITRO, ONCORHYNCHUS-MYKISS, CARBONIC-ANHYDRASE, AH RECEPTOR, DNA-DAMAGE, INDUCTION, LIVER, ERYTHROCYTES
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Akdeniz Üniversitesi Adresli: Hayır
Özet
The hazardous effects of pesticides on various metabolic pathways are a great problem for environmental health and should be well determined. In the present study, the authors treated rainbow trout with 0.6 mu g/L deltamethrin for 28 days and 1.6 mg/L 2,2-dichlorovinyl dimethyl phosphate for 21 days. After this time period, the authors observed alterations in mRNA expression levels of MT-A, MT-B and CYP-1A. Chronic exposure to low levels of pesticides may have a more significant effect on fish populations than acute poisoning. While both pesticides caused a significant increase on mRNA levels of MT-A and CYP-1A, MT-B mRNA levels were increased significantly only upon deltamethin administration. The significant increase in mRNA levels of the corresponding genes may be considered as a defence mechanism in addition to the antioxidants against oxidative stress, as well as a detoxification mechanism against adverse effects of pesticides.