Effect of intravenous nitroglycerin therapy on erythrocyte antioxidant enzymes

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Aliciguzel Y., Aktas S., Bozan H., Aslan M.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.20, no.3, pp.293-296, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1080/14756360500073320
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.293-296
  • Keywords: Glyceryl Trinitrate, erythrocyte, antioxidant enzymes, reactive oxygen species, ROS, NITRIC-OXIDE, GLYCERYL TRINITRATE, NITRATE TOLERANCE, DOUBLE-BLIND, GLUTATHIONE-PEROXIDASE, ISOSORBIDE DINITRATE, SUPEROXIDE ANION, MECHANISM, BIOTRANSFORMATION, INACTIVATION
  • Akdeniz University Affiliated: Yes

Abstract

Effect of intravenous nitroglycerin therapy on erythrocyte antioxidant enzymes.

Alicigüzel Y1, Aktaş S, Bozan H, Aslan M.

 

 

Abstract

Intravenous nitroglycerin (GTN) has been used as an anti-ischemic agent for the therapy of unstable and post-infarction angina. Nitric oxide (NO) and S-nitrosothiols constitute the biologically active species formed via nitroglycerin bioactivation. Increased levels of reactive oxygen species can diminish the therapeutic action of organic nitrates by scavenging donated NO and oxidizing tissue thiols important in nitrate biotransformation. Studies reported here show that the red cell activity of antioxidant enzymes, catalase and glutathione peroxidase, are significantly decreased after intravenous nitroglycerin treatment. Catalase activity (739.6 +/- 92.3 k/gHb) decreased to 440.1 +/- 111.9 and 459.8 +/- 130.7 k/gHb after 1 and 24 hr GTN infusion, respectively. Similarly, glutathione peroxidase activity (5.8 +/- 1.8 U/gHb) decreased to 3.2 +/- 1.7 and 3.8 +/- 1.1 U/g Hb after 1 and 24 hr GTN infusion, respectively. The reported decrease in antioxidant enzyme activities can lead to an oxidant milieu and contribute to the generation of nitrate tolerance.