LYSOPHOSPHATIDIC ACID MODIFIES THE RESPONSE OF PC3 PROSTATE CANCER CELLS TO CHEMOTHERAPEUTICS

Genc G. E., Sahin E., Sahin M., Gumuslu S.

WORLD CANCER RESEARCH JOURNAL, cilt.7, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7
  • Basım Tarihi: 2020
  • Doi Numarası: 10.32113/wcrj_20209_1687
  • Dergi Adı: WORLD CANCER RESEARCH JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Anahtar Kelimeler: Apoptosis, Cell proliferation, Docetaxel, Estramustine, Lysophosphatidic acid, Mitoxantrone, Prostate cancer, ESTRAMUSTINE, PROLIFERATION, LPA, SURVIVAL, PHOSPHORYLATION, MECHANISMS, APOPTOSIS, MIGRATION, INVASION, RECEPTOR
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective: Prostate cancer is the most frequently diagnosed cancer among men. Docetaxel, estramustine, and mitoxantrone are commonly used chemotherapy agents for the treatment of prostate cancer. However, lysophosphatidic acid (LPA), a biologically active glycerophospholipid derivative, induces proliferation and inhibits apoptosis in prostate cancer cells. The aim of this study was to investigate the effects of LPA against cell toxicity of docetaxel, estramustine and mitoxantrone.