WORLD CANCER RESEARCH JOURNAL, cilt.7, 2020 (ESCI)
Objective: Prostate cancer is the most frequently diagnosed cancer among men. Docetaxel, estramustine, and mitoxantrone are commonly used chemotherapy agents for the treatment of prostate cancer. However, lysophosphatidic acid (LPA), a biologically active glycerophospholipid derivative, induces proliferation and inhibits apoptosis in prostate cancer cells. The aim of this study was to investigate the effects of LPA against cell toxicity of docetaxel, estramustine and mitoxantrone.