The effect of FSH and activin A on Akt and MAPK1/3 phosphorylation in cultured bovine ovarian cortical strips

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TEPEKOY F., AKKOYUNLU G.

JOURNAL OF OVARIAN RESEARCH, cilt.9, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1186/s13048-016-0222-2
  • Dergi Adı: JOURNAL OF OVARIAN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Activin, FSH, Akt, MAPK, FOLLICLE-STIMULATING-HORMONE, RAT GRANULOSA-CELLS, PROTEIN-KINASE-B, IN-VITRO MATURATION, PRIMORDIAL FOLLICLES, PREANTRAL FOLLICLES, MESSENGER-RNA, IMMUNOHISTOCHEMICAL LOCALIZATION, SUPPORTS DEVELOPMENT, SECONDARY FOLLICLES
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: rhFSH and rhActA have been used in mammalian ovarian follicle culture systems for activation of follicular growth in vitro and suggested to be responsible for primordial follicle survival through MAPK and Akt pathways. The aim of our study was to determine the effects of rhFSH and rhActA on Akt, pAkt, MAPK1/3 and pMAPK1/3 protein levels in bovine ovarian cortical strips cultured in vitro.