The effect of FSH and activin A on Akt and MAPK1/3 phosphorylation in cultured bovine ovarian cortical strips

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TEPEKOY F., AKKOYUNLU G.

JOURNAL OF OVARIAN RESEARCH, vol.9, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2016
  • Doi Number: 10.1186/s13048-016-0222-2
  • Journal Name: JOURNAL OF OVARIAN RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Activin, FSH, Akt, MAPK, FOLLICLE-STIMULATING-HORMONE, RAT GRANULOSA-CELLS, PROTEIN-KINASE-B, IN-VITRO MATURATION, PRIMORDIAL FOLLICLES, PREANTRAL FOLLICLES, MESSENGER-RNA, IMMUNOHISTOCHEMICAL LOCALIZATION, SUPPORTS DEVELOPMENT, SECONDARY FOLLICLES
  • Akdeniz University Affiliated: Yes

Abstract

Background: rhFSH and rhActA have been used in mammalian ovarian follicle culture systems for activation of follicular growth in vitro and suggested to be responsible for primordial follicle survival through MAPK and Akt pathways. The aim of our study was to determine the effects of rhFSH and rhActA on Akt, pAkt, MAPK1/3 and pMAPK1/3 protein levels in bovine ovarian cortical strips cultured in vitro.