Collective equilibrium behaviour of ion channel gating in cell membranes: An Ising model formulation

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Erdem R.

JOURNAL OF BIOLOGICAL PHYSICS, cilt.32, sa.6, ss.523-529, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/s10867-007-9034-3
  • Dergi Adı: JOURNAL OF BIOLOGICAL PHYSICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.523-529
  • Anahtar Kelimeler: statistical mechanics, Ising model, transfer matrix method, squid giant axon, voltage-gated, ion channels, channel-channel cooperative interactions, STATISTICAL-MECHANICAL MODEL, PAIR APPROXIMATION, ELECTRIC-FIELDS, 2-STATE MODEL, VOLTAGE, TRANSITION, KINETICS
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

A statistical mechanical model for voltage-gated ion channels in cell membranes is proposed using the transfer matrix method. Equilibrium behavior of the system is studied. Representing the distribution of channels over the cellular membrane on a one-dimensional array with each channel having two states (open and closed) and incorporating channel-channel cooperative interactions, we calculate the fraction of channels in the open state at equilibrium. Experimental data obtained from batrachotoxin-modified sodium channels in the squid giant axon, using the cut-open axon technique, is best fit by the model when there is no interaction between the channels.