Potassium channels in the vasodilating action of levosimendan on the human umbilical artery
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, vol.13, no.4, pp.312-315, 2006 (SCI-Expanded)
- Publication Type: Article / Article
- Volume: 13 Issue: 4
- Publication Date: 2006
- Doi Number: 10.1016/j.jsgi.2006.02.005
- Journal Name: JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.312-315
- Keywords: human umbilical artery, levosimendan, potassium channels, smooth muscle, HEART-FAILURE, CALCIUM SENSITIZER, PORTAL-VEIN, RELAXATION, INODILATOR, OUTPUT, DRUG
- Akdeniz University Affiliated: Yes
Abstract
OBJECTIVE: Levosimendan is a calcium-sensitizing agent and inodilator working via potassium channels, which is under current investigation in the treatment of heart failure. We investigated the type of potassium channels that play a role on the dilatating effect of levosimendan on the contractile tones of the isolated human umbilical artery (HUA).