Expression of c-erbB-2 and p53 in breast carcinoma patients: Comparison with traditional prognostic factors and survival

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GURKAN A., ERDOGAN G., Erdogan O., PESTERELI E., OGUS M., KARAVELI S., ...More

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.32, no.5, pp.455-464, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 5
  • Publication Date: 2004
  • Doi Number: 10.1177/147323000403200502
  • Journal Name: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.455-464
  • Keywords: breast cancer, prognostic factors, disease relapse, c-erbB-2, p53, SURGICAL ADJUVANT BREAST, PROGESTERONE-RECEPTOR, ESTROGEN-RECEPTOR, CANCER PATIENTS, BOWEL PROJECT, PROTEIN, OVEREXPRESSION, MASTECTOMY, INDICATOR, ONCOGENE
  • Akdeniz University Affiliated: Yes

Abstract

We aimed to determine the correlations between standard clinicopathological factors and expression of c-erbB-2 and p53 proteins, and to investigate the significance of these variables in relapse and disease-free survival (DFS) in breast carcinoma patients. Data from 200 patients who had undergone mastectomy for breast carcinoma were evaluated. Significant correlations were found between c-erbB-2 positivity and high histological grade (grade 3) tumour, p53 positivity and high grade tumour, and age <60 years and oestrogen receptor negativity. Twenty-six patients (13%) developed a recurrence. Disease relapse was more frequent in patients who had axillary lymph node (ALN) metastasis, high grade tumour, c-erbB-2 positivity and p53 positivity; these variables were also associated with a shorter DFS. The effects of ALN metastasis and p53 positivity were significant. In conclusion, ALN metastasis and p53 positivity were important factors for predicting disease relapse in mastectomy-treated breast carcinoma patients; other clinicopathological criteria and c-erbB-2 positivity were not predictive.