Expression of c-erbB-2 and p53 in breast carcinoma patients: Comparison with traditional prognostic factors and survival
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.32, sa.5, ss.455-464, 2004 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 5
- Basım Tarihi: 2004
- Doi Numarası: 10.1177/147323000403200502
- Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.455-464
- Anahtar Kelimeler: breast cancer, prognostic factors, disease relapse, c-erbB-2, p53, SURGICAL ADJUVANT BREAST, PROGESTERONE-RECEPTOR, ESTROGEN-RECEPTOR, CANCER PATIENTS, BOWEL PROJECT, PROTEIN, OVEREXPRESSION, MASTECTOMY, INDICATOR, ONCOGENE
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Akdeniz Üniversitesi Adresli: Evet
Özet
We aimed to determine the correlations between standard clinicopathological factors and expression of c-erbB-2 and p53 proteins, and to investigate the significance of these variables in relapse and disease-free survival (DFS) in breast carcinoma patients. Data from 200 patients who had undergone mastectomy for breast carcinoma were evaluated. Significant correlations were found between c-erbB-2 positivity and high histological grade (grade 3) tumour, p53 positivity and high grade tumour, and age <60 years and oestrogen receptor negativity. Twenty-six patients (13%) developed a recurrence. Disease relapse was more frequent in patients who had axillary lymph node (ALN) metastasis, high grade tumour, c-erbB-2 positivity and p53 positivity; these variables were also associated with a shorter DFS. The effects of ALN metastasis and p53 positivity were significant. In conclusion, ALN metastasis and p53 positivity were important factors for predicting disease relapse in mastectomy-treated breast carcinoma patients; other clinicopathological criteria and c-erbB-2 positivity were not predictive.