Effects of prasugrel on membrane potential and contractile activity of rat ventricular myocytes

KÜÇÜK M., Celen M. C., Yamasan B. E., KUCUKSEYMEN S., ÖZDEMİR S.

PHARMACOLOGICAL REPORTS, cilt.70, sa.1, ss.156-160, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.pharep.2017.08.015
  • Dergi Adı: PHARMACOLOGICAL REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.156-160
  • Anahtar Kelimeler: Prasugrel, P2Y(12) receptor, Contractile function, Membrane potential, Nitric oxide, ACUTE CORONARY SYNDROMES, NITRIC-OXIDE, CLOPIDOGREL, TICAGRELOR, THIENOPYRIMIDINONES, THIENOPYRIDINES, INHIBITION, ADENOSINE, BLOCKADE, HEART
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Though prasugrel is one of the important P2Y(12) inhibitors currently in use for antiplatelet therapy, its potential effects on contractility and electrical activity of ventricular myocytes have not yet been investigated. Hence this study was designed to study the impact of prasugrel on contractile function and membrane potential of isolated ventricular myocytes.