Effects of prasugrel on membrane potential and contractile activity of rat ventricular myocytes
PHARMACOLOGICAL REPORTS, vol.70, no.1, pp.156-160, 2018 (SCI-Expanded)
- Publication Type: Article / Article
- Volume: 70 Issue: 1
- Publication Date: 2018
- Doi Number: 10.1016/j.pharep.2017.08.015
- Journal Name: PHARMACOLOGICAL REPORTS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.156-160
- Keywords: Prasugrel, P2Y(12) receptor, Contractile function, Membrane potential, Nitric oxide, ACUTE CORONARY SYNDROMES, NITRIC-OXIDE, CLOPIDOGREL, TICAGRELOR, THIENOPYRIMIDINONES, THIENOPYRIDINES, INHIBITION, ADENOSINE, BLOCKADE, HEART
- Akdeniz University Affiliated: Yes
Abstract
Background: Though prasugrel is one of the important P2Y(12) inhibitors currently in use for antiplatelet therapy, its potential effects on contractility and electrical activity of ventricular myocytes have not yet been investigated. Hence this study was designed to study the impact of prasugrel on contractile function and membrane potential of isolated ventricular myocytes.